PXD073644

PXD073644 is an original dataset announced via ProteomeXchange.

Title	Proteomic characterization of plasma extracellular vesicles of post-COVID-19 ME/CFS patients in comparison to healthy donors
Description	Blood plasma derived extracellular Vesicles (EVs) could be important in mediating cell-to-cell-contact and thereby induce functional changes in targeted cell. This might help to understand pathomechanisms of disease such as post-infectious Myalgic Enceplhalomyelitis /Chronic Fatigue Syndrome (ME/CFS). This chronic disease with higher prevalence in females is mainly induced by viral infections and also by SARS-CoV2 and the diagnostic options are still very limited. Therefore, the cargo of EVs such as proteins and different small RNAs might serve as a potential useful diagnostic tool. In this study we aimed to improve disease diagnosis for post-COVID 19 ME/CFS by identifying new protein markers in the cargo of plasma derived EVs from a female patient group in comparison to a matched healthy donor group.
HostingRepository	PRIDE
AnnounceDate	2026-08-24
AnnouncementXML	Submission_2026-08-23_16:10:17.129.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Martina Seifert
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	monohydroxylated residue; iodoacetic acid derivatized residue; deamidated residue
Instrument	impact II

Revision	Datetime	Status	ChangeLog Entry
0	2026-01-27 08:51:25	ID requested
⏵ 1	2026-08-23 16:10:17	announced

Seifert M, Sch, ä, fers J, Douglas FF, Schwarzburg C, Boristowski D, Birke A, Klein O, Sotzny F, Rubarth K, Windzio L, Beez CM, Peters CK, Wittke K, Scheibenbogen C, Greco A, Extracellular Vesicle Protein and MiRNA Signatures as Biomarkers for Post-Infectious ME/CFS Patients. Int J Mol Sci, 27(5):(2026) [pubmed]

10.3390/ijms27052314;

submitter keyword: Vesicle, pcME/CFS

Martina Seifert
contact affiliation	Charité Universitätsmedizin Berlin Institute of Medical Immunology
contact email	martina.seifert@charite.de
lab head
Martina Seifert
contact affiliation	Charité Universitätmedizin Berlin, Institute of Medical Immunology
contact email	martina.seifert@charite.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/08/PXD073644

PRIDE project URI

• PRIDE
  1. PXD073644
     1. Label: PRIDE project
     2. Name: Proteomic characterization of plasma extracellular vesicles of post-COVID-19 ME/CFS patients in comparison to healthy donors