PXD073640 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Total proteome of parental and IGF2BP3 CRISPR/Cas9 knockout HCT116 cells under control conditions and endoplasmic reticulum (ER) stress |
| Description | IGF2BP3 is an RNA-binding protein that regulates mRNA stability, translation, and localization. Using RNA-seq and PAR-CLIP analyses, we found that IGF2BP3 binds and regulates levels of mRNAs encoding proteins involved in the unfolded protein response, yet the impact of IGF2BP3 depletion on the proteome was not characterized. To determine the effect of IGF2BP3 knockout on the cellular response to ER stress, we performed total proteome analysis of colorectal carcinoma cell line HCT116 with IGF2BP3 CRISPR/Cas9 knockout in control and ER stress conditions. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-07-24 |
| AnnouncementXML | Submission_2026-07-23_23:46:24.588.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Markus Hartl |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-01-27 07:56:05 | ID requested | |
| ⏵ 1 | 2026-07-23 23:46:25 | announced | |
Publication List
Keyword List
| submitter keyword: IGF2BP3, ER stress, RNA-binding protein |
Contact List
| Gülsün Elif Karagöz |
|---|
| contact affiliation | Max Perutz Labs, Vienna BioCenter Campus (VBC), 1030 Vienna, Austria; Austria Medical University of Vienna, Center for Medical Biochemistry, 1030 Vienna, Austria |
| contact email | guelsuen.karagoez@meduniwien.ac.at |
| lab head | |
| Markus Hartl |
|---|
| contact affiliation | Max Perutz Labs, Mass Spectrometry Facility, Vienna Biocenter Campus (VBC), Dr. Bohr-Gasse 9, Vienna, Austria |
| contact email | proteomics@maxperutzlabs.ac.at |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD073640 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD073640
- Label: PRIDE project
- Name: Total proteome of parental and IGF2BP3 CRISPR/Cas9 knockout HCT116 cells under control conditions and endoplasmic reticulum (ER) stress
