PXD073612

PXD073612 is an original dataset announced via ProteomeXchange.

Title	Identification of FOXM1 Epitopes in Lung Cancer
Description	FOXM1 is highly expressed in various cancer types and considered a key driver of cancer progression. Accordingly, we evaluated the immunogenicity of FOXM1 and investigated the feasibility of targeting this transcription factor using T cell receptor (TCR) engineering. We identified epitopes derived from FOXM1 which were immunogenic on HLA-A*02:01, HLA-A*24:02, and HLA-A*23:01, endogenously-processed and presented, and resulted in T cell activation and cytotoxic T cell responses. Following the generation of TCR-T cells, sensitivity and specificity were confirmed by peptide dose-response and X-scan, respectively. Most importantly, adoptive transfer of TCR engineered T cells led to reduced tumor growth and prolonged survival in NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) strain murine models bearing FOXM1 expressing subcutaneous tumors. Our studies confirm the immunogenicity of FOXM1 and feasibility of targeting this tumor-associated antigen using TCR-engineering.
HostingRepository	PRIDE
AnnounceDate	2026-02-18
AnnouncementXML	Submission_2026-02-18_07:01:40.933.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Alex Jaeger
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480; Orbitrap Ascend

Revision	Datetime	Status	ChangeLog Entry
0	2026-01-26 20:27:55	ID requested
⏵ 1	2026-02-18 07:01:41	announced

Dataset with its publication pending

submitter keyword: Immunopeptidomics, FOXM1, lung cancer

Alex Jaeger
contact affiliation	Moffitt Cancer Center
contact email	alex.jaeger@moffitt.org
lab head
Alex Jaeger
contact affiliation	Moffitt Cancer Center
contact email	alex.jaeger@moffitt.org
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD073612
     1. Label: PRIDE project
     2. Name: Identification of FOXM1 Epitopes in Lung Cancer