⮝ Full datasets listing
PXD073541
PXD073541 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Using Aqueous Humor Proteomics to Investigate Intraocular Herpesvirus Infections |
| Description | Herpesviruses cause vision-threatening viral anterior uveitis (VAU) and acute retinal necrosis (ARN). This study employed aqueous humor (AH) proteomics to investigate the host response and pathological mechanisms in herpesvirus-induced uveitis. AH samples from patients with VAU caused by herpes simplex virus types 1 and 2 (HSV-1/2), varicella-zoster virus (VZV), and cytomegalovirus (CMV), as well as from patients with VZV-associated ARN, were analyzed using SWATH-MS. A spectral library of 558 proteins was established for quantitative analysis. The results revealed a core pathogenic signature common to all viral uvieits, characterized by upregulated innate immune and inflammatory pathways (e.g., complement and coagulation cascades, JAK-STAT, TNF-α, NF-κB) and downregulated homeostatic pathways (e.g., negative regulation of Wnt signaling, synapse organization). Despite these shared features, each virus exhibited distinct proteomic profiles. HSV-1 was associated with robust adaptive immunity (MHC class I presentation), while HSV-2 was linked to acute-phase response and Trail-mediated apoptosis. |
| HostingRepository | iProX |
| AnnounceDate | 2026-01-26 |
| AnnouncementXML | Submission_2026-01-25_23:22:14.241.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Qingqin Tao |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | TripleTOF 6600 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-01-25 23:21:58 | ID requested | |
| ⏵ 1 | 2026-01-25 23:22:14 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: LC-MS/MS, Herpesvirus Infections, Aqueous humor, Uveitis |
Contact List
| Xiaomin Zhang | |
|---|---|
| contact affiliation | Tianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin Eye Institute, Nankai University Affiliated Tianjin Eye Hospital; Clinical College of Ophthalmology, Tianjin Medical University |
| contact email | xzhang08@tmu.edu.cn |
| lab head | |
| Qingqin Tao | |
| contact affiliation | Department of Ophthalmology, The First People's Hospital of Hefei, The Third Affiliated Hospital of Anhui Medical University |
| contact email | 714195905@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
