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PXD073438

PXD073438 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleNerol as an Anti-quorum sensing and Therapeutic Agent against Acinetobacter baumannii Pneumonia
DescriptionNerol subinhibitory concentrations block A. baumannii quorum sensing, inhibiting AHL, biofilm formation, motility, and EPS production. Proteomics validated these phenotypes, showing synchronous downregulation of key virulence proteins including BfmS and MacB. ITC confirmed its binding to BfmS disrupts the BfmRS two-component system. In a mouse pneumonia model, it significantly reduced lung bacterial load, blocked the NF-κB/MAPK axis, decreased inflammatory expression, restored lung tissue structure, and showed no hepatotoxicity. This provides a safe, non-antibiotic strategy for treating carbapenem-resistant Acinetobacter baumannii pneumonia.
HostingRepositoryiProX
AnnounceDate2026-01-23
AnnouncementXMLSubmission_2026-01-23_00:55:21.939.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterHong Zeng
SpeciesList scientific name: Acinetobacter baumannii ATCC 19606 = CIP 70.34 = JCM 6841; NCBI TaxID: 575584;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Astral
Dataset History
RevisionDatetimeStatusChangeLog Entry
02026-01-23 00:55:06ID requested
⏵ 12026-01-23 00:55:22announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Acinetobacter baumannii, Nerol, Quorum sensing
Pneumonia
Contact List
Hong Zeng
contact affiliationYoujiang Medical University for Nationalities
contact emailzenghong0705@163.com
lab head
Hong Zeng
contact affiliationYoujiang Medical University for Nationalities
contact emailzenghong0705@163.com
dataset submitter
Full Dataset Link List
iProX dataset URI

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