⮝ Full datasets listing
PXD073437
PXD073437 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | HDL glycation signature link to the severity of CAD |
| Description | Glycation of apolipoprotein A-I (apoA-I) compromises its cardiovascular protection, yet its pathogenic landscape remains poorly defined. Using unbiased glycation proteomics, we profiled apoA-I glycation in HDL from 1,154 patients with type 2 diabetes mellitus with or without coronary atherosclerosis (CAS). CAS-associated glycation types, frequencies, and key sites enabled construction of an apoA-I glycation index. An engineered anti-glycation apoA-I mutant restored HDL reverse cholesterol transport and inhibited atherogenesis by preventing TR4-mediated suppression of macrophage cholesterol efflux. |
| HostingRepository | iProX |
| AnnounceDate | 2026-01-22 |
| AnnouncementXML | Submission_2026-03-19_00:34:27.523.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Qingrun Li |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-01-23 00:53:07 | ID requested | |
| 1 | 2026-02-05 00:48:48 | announced | |
| ⏵ 2 | 2026-03-19 00:34:28 | announced | 2026-03-19: Update info. |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: T2DM, atherosclerosis, HDL, apolipoprotein A-I, glycation modification |
Contact List
| Rong Zeng | |
|---|---|
| contact affiliation | ShanghaiTech University |
| contact email | zengrong@shanghaitech.edu.cn |
| lab head | |
| Qingrun Li | |
| contact affiliation | Shanghai Advanced Research Institute |
| contact email | liqr@sari.ac.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
