PXD073337

PXD073337 is an original dataset announced via ProteomeXchange.

Title	Longitudinal Proteomic Profiling of Bronchoalveolar Lavage Fluid (BALF) and Serum in Tuberculosis Patients
Description	The scope of this project is to investigate dynamic and persistent proteomic changes in tuberculosis (TB) patients during the course of treatment by analyzing paired bronchial alveolar lavage fluid (BALf) and serum samples collected at diagnosis and after 25 weeks of therapy. By comparing patient samples to those from healthy community controls, the study aims to identify protein signatures that reflect both local (pulmonary) and systemic host responses, providing insight into treatment-associated changes and the potential risk of disease recurrence. We developed and applied a sample-specific processing workflow that includes bacterial inactivation steps, ensuring compatibility with downstream applications such as metabolomics analysis. Proteomic data were acquired using a data-independent acquisition (DIA) approach with a library-free analysis strategy, followed by a robust two-step imputation method to address missing values. The resulting high-confidence proteome datasets offer a valuable resource for future comparative analyses and biomarker discovery.
HostingRepository	PRIDE
AnnounceDate	2026-03-18
AnnouncementXML	Submission_2026-03-17_17:03:12.012.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Luisa Nieto
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; scientific name: Mycobacterium tuberculosis H37Rv; NCBI TaxID: NEWT:83332;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2026-01-21 03:53:59	ID requested
⏵ 1	2026-03-17 17:03:12	announced

Dataset with its publication pending

submitter keyword: None

Karen Dobos
contact affiliation	Professor, Microbiology, Immunology, and Pathology Mycobacteria Research Laboratories Scientific Director, Rocky Mountain Regional Biocontainment Laboratory Editor-in-chief, BMC Mycobacteria
contact email	Karen.Dobos@ColoState.edu
lab head
Luisa Nieto
contact affiliation	Colorado State University
contact email	luisa.nieto_ramirez@colostate.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD073337

PRIDE project URI

• PRIDE
  1. PXD073337
     1. Label: PRIDE project
     2. Name: Longitudinal Proteomic Profiling of Bronchoalveolar Lavage Fluid (BALF) and Serum in Tuberculosis Patients