PXD073288 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Plasma EVs-Derived Complement Proteins as Biomarkers of Sarcopenia Progression in Longitudinal Cohorts |
| Description | Sarcopenia is characterized by progressive loss of muscle mass, strength, and physical performance, yet current diagnostic tools are limited for practical and longitudinal monitoring. To explore alternative biomarkers, we performed quantitative proteomic profiling of plasma-derived extracellular vesicles (EVs) in the community-based Korean Frailty and Aging Cohort Study (KFACS). Longitudinal analysis revealed that EV-associated complement proteins, particularly C2 and C4B, were strongly associated with declines in gait speed and elevated in individuals with worsened outcomes over two years. Complement pathway enrichment and associations with inflammatory and aging-related signatures underscored their biological relevance. Independent validation in the hospital-based OsteoSarcopenia cohort at Seoul National University Bundang Hospital confirmed the predictive value of C2 and C1R for gait speed and SPPB decline, with AUC values exceeding 0.7. for clinically relevant measures. These findings position EV-derived complement proteins as promising circulating biomarkers for sarcopenia progression and offer insight into their broader role in aging-related processes. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-09-07 |
| AnnouncementXML | Submission_2026-09-07_05:03:24.573.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Ji Yeon Kim |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | iodoacetic acid derivatized residue |
| Instrument | TripleTOF 5600 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-01-20 08:45:28 | ID requested | |
| ⏵ 1 | 2026-09-07 05:03:25 | announced | |
Publication List
| Kim JY, Kong SH, Han D, Gil TH, Kim HS, Kim M, Kim JH, Park SS, Park SJ, Jhang HC, Won CW, Jeon OH, Plasma Extracellular Vesicles-Derived Complement Proteins as Biomarkers of Sarcopenia Progression in Longitudinal Cohorts. J Cachexia Sarcopenia Muscle, 17(4):e70350(2026) [pubmed] |
| 10.1002/jcsm.70350; |
Keyword List
| submitter keyword: Extracellular vesicles, sarcopenia, biomarkers, aging, complement proteins |
Contact List
| Ok Hee Jeon |
|---|
| contact affiliation | Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Republic of Korea |
| contact email | ojeon@korea.ac.kr |
| lab head | |
| Ji Yeon Kim |
|---|
| contact affiliation | Korea University |
| contact email | marcia9812@korea.ac.kr |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD073288 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD073288
- Label: PRIDE project
- Name: Plasma EVs-Derived Complement Proteins as Biomarkers of Sarcopenia Progression in Longitudinal Cohorts
