⮝ Full datasets listing
PXD073272
PXD073272 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | The role of BAF60C in type 2 diabetes |
| Description | This research identify reduced expression of BAF60C in diabetic islets and demonstrate that altered β-cell BAF60C levels strongly influence metabolic homeostasis. Genetic loss of BAF60C in β-cells exacerbates hyperglycemia and islet dysfunction under metabolic stress, whereas β-cell–specific restoration of BAF60C produces protective effects. These findings establish BAF60C as an important regulator of β-cell integrity and disease progression in T2D. |
| HostingRepository | iProX |
| AnnounceDate | 2026-01-29 |
| AnnouncementXML | Submission_2026-02-06_01:38:52.804.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Zhuoying Yang |
| SpeciesList | scientific name: Rattus norvegicus; NCBI TaxID: 10116; scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | LTQ Orbitrap |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-01-20 00:49:26 | ID requested | |
| ⏵ 1 | 2026-02-06 01:38:53 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: BAF60C, beta-cell, macrophage, mRNA decay, nucleolar stress, diabetes |
Contact List
| Zhuoxian Meng | |
|---|---|
| contact affiliation | Zhejiang University School of Medicine |
| contact email | zxmeng@zju.edu.cn |
| lab head | |
| Zhuoying Yang | |
| contact affiliation | Zhejiang University School of Medicine |
| contact email | zhyyang20@zju.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
