PXD073111

PXD073111 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic Analysis of Ginkgolic Acid Targets in HCCLM3 Cells via DARTS-LC-MS/MS
Description	This study aims to identify the potential protein targets of Ginkgolic Acid in human hepatocellular carcinoma HCCLM3 cells using the Drug Affinity Responsive Target Stability (DARTS) assay combined with LC-MS/MS proteomics. Whole cell lysates from Ginkgolic Acid-treated and vehicle control (DMSO) HCCLM3 cells were subjected to limited proteolysis with proteinase K. The digested protein samples were separated by SDS-PAGE, and differential protein bands were excised, digested in-gel, and analyzed by mass spectrometry. The raw data will be used to identify proteins whose stability is altered upon Ginkgolic Acid binding, providing insights into its anti-tumor mechanisms.
HostingRepository	PRIDE
AnnounceDate	2026-03-30
AnnouncementXML	Submission_2026-03-29_16:15:36.661.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Huizhen Zou
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2026-01-15 02:53:41	ID requested
⏵ 1	2026-03-29 16:15:37	announced

Publication List

Liu R, Zhang Y, Zou H, Zhang M, Yang Z, Liao K, Wang G, Liu B, Tang L, Kang X, Zheng S, chaperone-mediated autophagy-dependent GPX4 degradation. Pharm Biol, 64(1):514-535(2026) [pubmed]
10.1080/13880209.2026.2646350;

Liu R, Zhang Y, Zou H, Zhang M, Yang Z, Liao K, Wang G, Liu B, Tang L, Kang X, Zheng S, chaperone-mediated autophagy-dependent GPX4 degradation. Pharm Biol, 64(1):514-535(2026) [pubmed]

10.1080/13880209.2026.2646350;

Keyword List

submitter keyword: None

submitter keyword: None

Contact List

shuguo zheng
contact affiliation	Department of Hepatobiliary Surgery, the First Affiliated Hospital(Southwest Hospital) of Army Military Medical University, Chongqing 400038, China.
contact email	shuguozh@tmmu.edu.cn
lab head
Huizhen Zou
contact affiliation	THE GENERAL HOSPITAL OF WESTERN THEATER COMMAND PLA
contact email	zouhuizhen1998@gmail.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD073111
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD073111

PRIDE project URI

Repository Record List

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