⮝ Full datasets listing
PXD073084
PXD073084 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic Analysis of Addiction-Related Brain Regions in Mice Following Conditioned Place Preference Training with 2-Fluoroketamine and Ketamine；Proteomic Profiling of Primary Mouse Neurons Following Exposure to 2-Fluoroketamine and Ketamine |
| Description | To evaluate the addictive potential of 2-FDCK (20mg/kg) and KET (20mg/kg) in mice, we employed a standard conditioned place preference (CPP) paradigm. During the conditioning phase, mice learned to associate the abused drug reward with a specific contextual chamber. After a 21-day conditioning period, the mice were reintroduced to the CPP apparatus and allowed to freely explore both chambers in the absence of the drug. Subsequently, samples from the hippocampus, mPFC, and VTA were collected and pretreated. We also extracted primary neurons from the mouse prefrontal cortex as an in vitro model, exposed them to 2-FDCK or KET (30uM), and collected the samples. All samples were then analyzed using an Eksigent® M5+TripleTOF® 5600+ system. All data acquisition was performed using Analyst TF 1.7 software, and the IDA data were searched against the database using ProteinPilot™ software. |
| HostingRepository | iProX |
| AnnounceDate | 2026-01-14 |
| AnnouncementXML | Submission_2026-02-11_00:03:10.320.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jiaying Wang |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | TripleTOF 5600 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-01-14 18:31:30 | ID requested | |
| ⏵ 1 | 2026-02-11 00:03:10 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: 2-Fluoroketamine, Ketamine, Addiction, Brain, Primary Neurons |
Contact List
| Yuan Xie | |
|---|---|
| contact affiliation | China Pharmaceutical University |
| contact email | yuanxie@cpu.edu.cn |
| lab head | |
| Jiaying Wang | |
| contact affiliation | China Pharmaceutical University |
| contact email | 13022512223@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
