⮝ Full datasets listing
PXD073053
PXD073053 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Tissue-layer resolved proteome landscape of Crohns disease strictures highlights potential drivers of fibrosis progression |
| Description | The chronic inflammation of Crohns disease frequently leads to fibrosis and muscular hypertrophy of the intestinal wall. This often culminates in strictures, a serious condition lacking directed therapy. Severe pathological changes occur in the submucosa and muscularis propria intestinal wall layers of strictures, yet stricture-associated proteome changes in these layers is unexplored. We perform unbiased proteomics on submucosa and muscularis propria microdissected from transmural sections of strictured and non-strictured ileum. Proteome changes in stricture submucosa reflect a transition from homeostasis to tissue remodeling, inflammation and smooth muscle alterations. Top submucosa features include reduced vascular components and lipid metabolism proteins accompanied by increased proteins with immune-, matrix- or stress functions including CTHRC1, TNC, IL16, MZB1 and TXNDC5. In parallel, predominant changes in stricture muscularis propria include increased matrix (POSTN) and immune (mast cell CPA3) proteins alongside decreased proteins with lipid metabolic, mitochondrial or key muscle functions. Finally, trends of differentially expressed proteins along non-stricture submucosa suggest progressive profibrotic tissue remodeling and muscle expansion as proximity to stricture increases. The comprehensive proteome map presented here offers unique layer-resolved insight into the stricture microenvironment and potential drivers of fibrotic disease, providing a unique resource to fuel research toward new biomarkers and therapeutic targets. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-01-28 |
| AnnouncementXML | Submission_2026-01-28_05:32:42.153.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Johannes Fuchs |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | Oxidation; TMTpro; Carbamidomethyl |
| Instrument | Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-01-14 01:12:00 | ID requested | |
| ⏵ 1 | 2026-01-28 05:32:42 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Crohns disease strictures, proteomics, intestinal fibrosis, fibrostenosis, DatasetType:Proteomics |
Contact List
| Mary Jo Wick | |
|---|---|
| contact affiliation | Department of Microbiology and Immunology, Institute for Biomedicine, Sahlgrenska Academy, University of Gothenburg, Box 435, 405 30 Gothenburg |
| contact email | mary-jo.wick@immuno.gu.se |
| lab head | |
| Johannes Fuchs | |
| contact affiliation | University of Gothenburg |
| contact email | johannes.fuchs@gu.se |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v11/MSV000100468/ |
