PXD073047

PXD073047 is an original dataset announced via ProteomeXchange.

Title	Zinc-dependent Zip7-MAZ-MYBL2 axis promotes prostate cancer metastasis
Description	Screening reveals that a zinc transporter Zip7 was upregulated in metastatic PCa and related to poor progression. Zip7 silencing inhibits PCa cell migration and invasion in vitro and bone-metastasis in vivo. Mechanistically, we identify that Zip7 mainly interacts with MAZ in cytoplasm to facilitate MAZ nuclear import and nuclear MAZ was up-regulated in metastatic prostate cancer tissues and positively associated with Zip7 expression, which promotes PCa bone metastasis. Furthermore, our RNA-seq studies reveal that Zip7 facilitates MAZ nuclear import to promote MYBL2 transcription. Strikingly, we show in intraarterial injected-bone metastasis xenograft model that targeting Zip7 by its inhibitor markedly suppressed PCa bone metastasis. Collectively, our findings identify Zip7 is an important regulator of PCa metastasis and targeting Zinc-dependent Zip7-MAZ-MYBL2 could be a valuable strategy to ameliorate advanced PCa metastasis.
HostingRepository	iProX
AnnounceDate	2026-01-14
AnnouncementXML	Submission_2026-01-14_00:08:21.805.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yunqiang Xiong
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2026-01-14 00:07:57	ID requested
⏵ 1	2026-01-14 00:08:22	announced

Dataset with its publication pending

submitter keyword: Zip7, Zinc, MAZ, Prostate cancer metastasis, MYBL2

Bin Fu
contact affiliation	The First Affiliated Hospital of Nanchang University
contact email	urodoc@ncu.edu.cn
lab head
Yunqiang Xiong
contact affiliation	The First Affiliated Hospital of Nanchang University
contact email	xyqncu@qq.com
dataset submitter

iProX dataset URI