⮝ Full datasets listing
PXD072975
PXD072975 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Triglyceride induces endoplasmic reticulum lipid bilayer stress to activate PERK and enhance antifungal immunity |
| Description | Triglyceride synthesis promotes the activation of C-type lectin receptors signaling pathway upon fungal infection. Triglyceride synthesis induces endoplasmic reticulum lipid bilayer stress and activates the PERK kinase after fungal stimulation. PERK mediates autophagic degradation of SHP-1 to amplify the SYK-associated antifungal signaling. |
| HostingRepository | iProX |
| AnnounceDate | 2026-01-12 |
| AnnouncementXML | Submission_2026-03-02_19:45:46.034.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Han Wu |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | LTQ Orbitrap |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-01-12 17:29:19 | ID requested | |
| 1 | 2026-01-12 17:29:56 | announced | |
| ⏵ 2 | 2026-03-02 19:45:47 | announced | 2026-03-03: Add Publication. |
Publication List
| Wu H, Shui Q, Luan X, Wang K, Zhao W, Qi X, Liu B, Sun W, Gao C, Triglycerides induce endoplasmic reticulum lipid bilayer stress to activate PERK and enhance antifungal immunity. Cell Rep, 45(2):116976(2026) [pubmed] |
Keyword List
| submitter keyword: Antifungal immunity, Triglycerides, PERK, Lipid bilayer stress, Drug target |
Contact List
| Chengjiang Gao | |
|---|---|
| contact affiliation | School of Biomedical Sciences, Shandong University |
| contact email | cgao@sdu.edu.cn |
| lab head | |
| Han Wu | |
| contact affiliation | School of Biomedical Sciences, Shandong University |
| contact email | 986080632@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
