PXD072925

PXD072925 is an original dataset announced via ProteomeXchange.

Title	Quantitative Proteomic Analysis Reveals Central Metabolic Pathways Affect Norfloxacin Tolerance in Vibrio alginolyticus
Description	Antibiotic tolerance often involves reversible metabolic reprogramming. Here, we applied DIA-based quantitative proteomics to profile Vibrio alginolyticus (V. alginolyticus) under norfloxacin (NOR) exposure and observed widespread decreases in protein abundance, consistent with a global metabolic downshift. The most prominent changes were in central carbon and energy metabolism, encompassing the Embden–Meyerhof–Parnas (EMP), pentose phosphate (PPP), and tricarboxylic acid (TCA) pathways, alongside amino acid metabolism and oxidative phosphorylation. . The study utilizes advancedproteomics techniques, including LC-/MS/MS,to uncoverdifferential protein expression patterns.
HostingRepository	iProX
AnnounceDate	2026-01-11
AnnouncementXML	Submission_2026-01-11_23:25:35.039.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chenghao Shen
SpeciesList	scientific name: Vibrio alginolyticus NBRC 15630 = ATCC 17749; NCBI TaxID: 1219076;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 240

Revision	Datetime	Status	ChangeLog Entry
0	2026-01-11 23:25:15	ID requested
⏵ 1	2026-01-11 23:25:35	announced

Dataset with its publication pending

submitter keyword: V. alginolyticus, NOR tolerance, quantitative proteomics, metabolic remodeling, central carbon metabolism

Xiangmin Lin
contact affiliation	Fujian Agriculture and Forestry University
contact email	313461278@qq.com
lab head
Chenghao Shen
contact affiliation	Fujian Agriculture and Forestry University
contact email	316627587@qq.com
dataset submitter

iProX dataset URI