⮝ Full datasets listing
PXD072924
PXD072924 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic Profiling of Plasma Extracellular Vesicles Reveals a Therapeutically Targetable Liver-Heart Axis in Cardiac Transplantation |
| Description | Extracellular vesicles (EVs)-mediated inter-organ communication represents a promising frontier in transplant immunology; however, its role in cardiac allograft rejection remains poorly characterized. We performed proteomic profiling of plasma-derived EVs in a rat heterotopic heart transplantation model. By comparing allogeneic and isogeneic graft recipients to sham-operated controls, we identified significant enrichment of hepatic-specific proteins in circulating EVs during acute rejection, with ATIII emerging as a top candidate. |
| HostingRepository | iProX |
| AnnounceDate | 2026-01-11 |
| AnnouncementXML | Submission_2026-04-23_23:59:11.749.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Shiyu Dai |
| SpeciesList | scientific name: Rattus norvegicus; NCBI TaxID: 10116; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-01-11 23:23:49 | ID requested | |
| ⏵ 1 | 2026-04-23 23:59:12 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Heart transplantation |
Contact List
| Zhenya Shen | |
|---|---|
| contact affiliation | First Affiliated Hospital, Soochow University |
| contact email | uuzyshen@aliyun.com |
| lab head | |
| Shiyu Dai | |
| contact affiliation | First Affiliated Hospital, Soochow University |
| contact email | 15629039156@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
