PXD072838

PXD072838 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	DIA-PASEF Proteomic Profiling of Metabolic Regulation of Extracellular Vesicle Uptake
Description	This project uses untargeted proteomics to investigate how cellular metabolic state and metabolite adjuvants regulate extracellular vesicle (EV) uptake in neuroblastoma cells. Proteomic profiling was performed on cells cultured in in vivo–like medium (HPLM) or standard medium, as well as on HPLM-conditioned cells treated with or without metabolite adjuvants. Comparative pathway analyses identified metabolic rewiring under physiologic conditions and revealed upregulation of endocytosis-associated pathways following metabolite supplementation. These proteomics data support a model in which modulation of the cellular metabolome enhances EV uptake primarily through increased endocytic activity.
HostingRepository	PRIDE
AnnounceDate	2026-03-19
AnnouncementXML	Submission_2026-03-19_11:15:32.687.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ryan McClure
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF Ultra 2

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2026-01-08 19:18:52	ID requested
⏵ 1	2026-03-19 11:15:33	announced

Publication List

10.1016/J.CELBIO.2026.100409;

10.1016/J.CELBIO.2026.100409;

Keyword List

submitter keyword: None

submitter keyword: None

Contact List

Ryan McClure
contact affiliation	MS Omics, Biohub Chicago, USA
contact email	ryan.mcclure@biohub.org
lab head
Ryan McClure
contact affiliation	Biohub Chicago
contact email	ryan.mcclure@biohub.org
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD072838
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD072838

PRIDE project URI

Repository Record List

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