PXD072757

PXD072757 is an original dataset announced via ProteomeXchange.

Title	Comparative plasma proteomics of COVID-19 and Dengue patients with relevance to cardiovascular-associated pathways
Description	The COVID-19 pandemic has highlighted the association between SARS-CoV-2 infection and a range of systemic complications, including cardiovascular abnormalities. Increasing clinical evidence indicates that COVID-19 patients are at an elevated risk of myocardial injury, arrhythmias, myocarditis, and thromboembolic events. To better characterize molecular alterations associated with infection-related cardiovascular risk, we performed a comparative proteomic analysis of human plasma samples obtained from healthy controls, COVID-19 patients, and Dengue patients. High-resolution liquid chromatography–tandem mass spectrometry (LC–MS/MS) was used to identify and quantify circulating proteins, followed by bioinformatic analyses to evaluate functional enrichment and pathway associations. The dataset reveals infection-associated alterations in proteins linked to inflammatory signaling, coagulation cascades, immune activation, and vascular homeostasis. Comparative analyses highlight both shared and infection-specific proteomic signatures between COVID-19 and Dengue plasma samples. This proteomic dataset provides a resource for exploring circulating molecular changes associated with viral infections and their potential links to cardiovascular complications, and is intended to support further mechanistic and translational investigations.
HostingRepository	PRIDE
AnnounceDate	2026-05-20
AnnouncementXML	Submission_2026-05-20_04:19:12.059.xml
DigitalObjectIdentifier	https://doi.org/10.6019/PXD072757
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Trina Roy
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2026-01-07 09:19:54	ID requested
⏵ 1	2026-05-20 04:19:12	announced

10.6019/PXD072757;

submitter keyword: Human, Heart Disease, Plasma, Dengue, Covid, Orbitrap LC-MS/MS

Dr. Subhajit Biswas
contact affiliation	Infectious Diseases and Immunology Division, CSIR – Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Jadavpur, Kolkata-700032, Wet Bengal, India.
contact email	subhajit.biswas@iicb.res.in
lab head
Trina Roy
contact affiliation	CSIR-SRF, CSIR - Indian Institute of Chemical Biology
contact email	animetrina18@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD072757

PRIDE project URI

• PRIDE
  1. PXD072757
     1. Label: PRIDE project
     2. Name: Comparative plasma proteomics of COVID-19 and Dengue patients with relevance to cardiovascular-associated pathways