PXD072756

PXD072756 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	ACSL4-Associated Lipid Metabolism is a Distinct Therapeutic Vulnerability in KMT2A-Rearranged Acute Myeloid Leukemia
Description	We were interested in proteomic changes after depletion of the lipid metabolic gene Acyl-CoA Synthetase Long Chain Family Member 4 (ACSL4) in human acute myleoid leukemia (AML) cell lines. We compared global protein alterations upon ACSL4 knockdown in one AML cell line harboring a lysine methyltransferase 2A (KMT2A) gene rearrangement (NOMO1) and two KMT2A WT AML cell lines (K562, MOLM16).
HostingRepository	PRIDE
AnnounceDate	2026-01-15
AnnouncementXML	Submission_2026-01-15_10:23:38.917.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Alexander Wurm
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2026-01-07 08:33:26	ID requested
⏵ 1	2026-01-15 10:23:39	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: None

submitter keyword: None

Contact List

Alexander. Wurm
contact affiliation	Department of Pediatric Hematology and Oncology, National Center for Tumor Diseases (NCT/UCC) Dresden
contact email	alexander.wurm@nct-dresden.de
lab head
Alexander Wurm
contact affiliation	National Center for Tumor Diseases (NCT/UCC) Dresden
contact email	alexander.wurm@nct-dresden.de
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD072756
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD072756

PRIDE project URI

Repository Record List

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