⮝ Full datasets listing
PXD072694
PXD072694 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Targeting CD4 + T cell epitopes conserved across bacterial species for broadly acting bacterial vaccines |
| Description | Antimicrobial resistance is a global health threat, and alternative therapeutic interventions to replace failing antibiotics are urgently needed. Vaccines are effective tools to combat bacterial infection and mitigate multi-drug resistance, however, the selection of bacterial antigens as vaccine candidates remains challenging. Here we use immunopeptidomics to mine for CD4 T-cell vaccine targets in methicillin-resistant Staphylococcus aureus - a clinically significant, antibiotic-resistant bacterium that is susceptible to T cell meditated control. We identified a novel, highly conserved, immunodominant CD4 T cell epitope in S. aureus that is derived from the core DNA binding protein Hu (Hup). This epitope is shared across a range of clinically relevant bacteria and cross-species reactive Hup specific CD4 T cells are found in both mice and humans. Immunisation with the Hup epitope resulted in the development of broadly protective CD4 T cell immunity capable of limiting disease severity following infection with different bacterial species, including S. aureus and Streptococcus pneumoniae. A vaccine incorporating antigenic targets derived from conserved core genes that are shared across bacterial species, can confer broad spectrum protection against a range of clinically significant bacteria, including antibiotic-resistant strains. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-01-06 |
| AnnouncementXML | Submission_2026-01-06_13:23:50.710.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | A. Braun |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; scientific name: Staphylococcus aureus; NCBI TaxID: 1280; |
| ModificationList | Acetyl; Oxidation; Deamidated |
| Instrument | timsTOF Pro 2 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-01-05 21:50:25 | ID requested | |
| ⏵ 1 | 2026-01-06 13:23:51 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: dendritic cell, Mutu, Staphylococcus aureus, MHC II, antigen presentation, immunopeptidomics, DatasetType:Proteomics, DatasetType:Other (Immunopeptidomics) |
Contact List
| Linda Wakim | |
|---|---|
| contact affiliation | University of Melbourne |
| contact email | linda.wakim@unimelb.edu.au |
| lab head | |
| A. Braun | |
| contact affiliation | Monash |
| contact email | assolbraun@web.de |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v11/MSV000100384/ |
