PXD072598 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteome-wide Profiling of Diverse Pentafluorobenzenesulfonamide Reactive Fragments |
| Description | A unified synthesis of diverse pentafluorobenzenesulfonamide reactive fragments was developed which was based on the reaction between diverse, readily-available substrates and rhodium nitrenoid intermediates formed from pentafluorobenzenesulfonamide. The approach enabled the synthesis of 21 reactive fragments whose diversity stemmed from both that of the substrates, and the rich chemistry of rhodium nitrenoids. Five of the reactive fragments were profiled against HeLa cell lysate, which demonstrated that the constellation of modified proteins was critically dependent on the specific reactive fragment used. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-03-28 |
| AnnouncementXML | Submission_2026-03-28_03:29:55.925.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Julian Chesti |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | timsTOF Pro 2 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-01-03 03:37:18 | ID requested | |
| ⏵ 1 | 2026-03-28 03:29:56 | announced | |
Publication List
Keyword List
| submitter keyword: iodoacetamide alkyne,Pull-down proteomics, covalent fragment screening, DDA-PASEF, pentafluorobenzenesulfonamide, label-free quantification |
Contact List
| Adam Nelson |
|---|
| contact affiliation | Professor of Chemical Biology, School of Chemistry, University of Leeds, United Kingdom |
| contact email | A.S.Nelson@leeds.ac.uk |
| lab head | |
| Julian Chesti |
|---|
| contact affiliation | University of Leeds |
| contact email | nmsv885@leeds.ac.uk |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD072598 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD072598
- Label: PRIDE project
- Name: Proteome-wide Profiling of Diverse Pentafluorobenzenesulfonamide Reactive Fragments
