⮝ Full datasets listing
PXD072548
PXD072548 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Doubling Proteome Coverage in Spatial Proteomics: MOFs-assisted Method for Trace Tissue Analysis |
| Description | Spatial proteomics of trace tissues isolated via LCM is limited by insufficient protein identification depth and coverage. We introduce a qMOFs-assisted protein preparation workflow into LCM-spatial proteomics, doubling the number of identified proteins (100 μm × 100 μm mouse myocardium) with high reproducibility. Building on this enhancement, we uncover cardiac aging-related cytoskeletal destabilization and mitochondrial dysregulation in perivascular myocardium, identifying Rack1 as a key node. |
| HostingRepository | iProX |
| AnnounceDate | 2025-12-30 |
| AnnouncementXML | Submission_2025-12-30_23:44:21.466.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yuankang Zhu |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-12-30 23:44:06 | ID requested | |
| ⏵ 1 | 2025-12-30 23:44:21 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Spatial proteomics, Metal-organic frameworks, Laser capture microdissection, Trace sample analysis, Cardiac aging |
Contact List
| Xianting Ding | |
|---|---|
| contact affiliation | Shanghai Jiao Tong University |
| contact email | dingxianting@sjtu.edu.cn |
| lab head | |
| Yuankang Zhu | |
| contact affiliation | Shanghai Jiao Tong University |
| contact email | zyk3336@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
