PXD072542

PXD072542 is an original dataset announced via ProteomeXchange.

Title	TSC1 mitigates bevacizumab-induced antinociception impairment
Description	In this study, we investigated how bevacizumab influences morphine antinociception and dissected the underlying molecular mechanisms within the mPFC. We hypothesized that VEGF-A inhibition disrupts neuronal autophagy by reducing TSC1 expression and activating mTOR, thereby compromising morphine analgesic signaling. We further examined whether genetic or pharmacological interventions targeting this axis could restore morphine efficacy under VEGF-A blockade. Through integrated behavioral, proteomic, molecular, ultrastructural, and in vivo calcium-imaging analyses, we identified a mechanistic link between VEGF-A blockade and impaired opioid function, and explored potential therapeutic strategies to mitigate this interaction in clinical settings where anti-VEGF therapy is employed.
HostingRepository	iProX
AnnounceDate	2025-12-31
AnnouncementXML	Submission_2025-12-30_23:30:37.859.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Quan Ma
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2025-12-30 23:29:40	ID requested
⏵ 1	2025-12-30 23:30:38	announced

Dataset with its publication pending

submitter keyword: Vascular endothelial growth factor A, Bevacizumab, Morphine, Antinociception, Medial prefrontal cortex, Tuberous sclerosis complex 1, Autophagy

Quan Ma
contact affiliation	Shenzhen Third People's Hospital
contact email	maq2018@mail.sustech.edu.cn
lab head
Quan Ma
contact affiliation	Shenzhen Third People's Hospital
contact email	maq2018@mail.sustech.edu.cn
dataset submitter

iProX dataset URI