⮝ Full datasets listing
PXD072505
PXD072505 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Nuclear polysaccharides maintain H3K9me3-heterochromatin and genomic stability |
| Description | Polysaccharides are traditionally confined to the cell surface and extracellular space, whereas their nuclear roles remain unclear. Here, we show that N-glycans are present in the nucleus and modify inner nuclear membrane (INM) proteins across multiple cell types. Disruption of INM protein N-glycosylation reduces H3K9me3 in lamina-associated domains and induces genomic instability by impairing SETDB1 association with the INM. Notably, canonical ER N-glycan biosynthetic machinery contributes to INM protein N-glycosylation. Our findings reveal a previously unrecognized nuclear function of polysaccharides. |
| HostingRepository | iProX |
| AnnounceDate | 2025-12-30 |
| AnnouncementXML | Submission_2026-03-10_17:23:24.646.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Zhida Zhang |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-12-29 18:12:35 | ID requested | |
| ⏵ 1 | 2026-03-10 17:23:25 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Glycoproteomics, N-glycosylation of INM proteins |
Contact List
| Shisheng Sun | |
|---|---|
| contact affiliation | Northwest University |
| contact email | suns@nwu.edu.cn |
| lab head | |
| Zhida Zhang | |
| contact affiliation | Northwest University |
| contact email | zhida0717@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
