PXD072371 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Glycoproteome-Wide Discovery of Cortical Glycoproteins That May Provide Cognitive Resilience in Older Adults |
| Description | Background and Objectives Molecular omics studies have identified proteins related to cognitive resilience but unrelated to Alzheimer disease and Alzheimer disease–related dementia (AD/ADRD) pathologies. Posttranslational modifications of proteins with glycans can modify protein function. In this study, we identified glycopeptiforms associated with cognitive resilience. Methods We studied brains from adults with annual cognitive testing with postmortem indices of 10 AD/ADRD pathologies and proteome-wide data from dorsal lateral prefrontal cortex (DLPFC). We quantified 11, 012 glycopeptiforms from DLPFC using liquid chromatography with tandem mass spectrometry. We used linear mixed-effects models to identify glycopeptiforms associated with cognitive decline correcting for multiple comparisons (p < 5 × 10−6). Then, we regressed out the effect of AD/ADRD pathologies to identify glycopeptiforms that may provide cognitive resilience. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-12-24 |
| AnnouncementXML | Submission_2025-12-24_14:29:22.592.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD072371 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Yishai Levin |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-12-23 15:39:03 | ID requested | |
| ⏵ 1 | 2025-12-24 14:29:23 | announced | |
Publication List
| Buchman AS, Yu L, Klein HU, Zammit AR, Oveisgharan S, Nag S, Tickotsky N, Levy H, Seyfried N, Morgenstern D, Levin Y, Schnaider Beeri M, Bennett DA, Glycoproteome-Wide Discovery of Cortical Glycoproteins That May Provide Cognitive Resilience in Older Adults. Neurology, 102(7):e209223(2024) [pubmed] |
| 10.1212/wnl.0000000000209223; |
| 10.6019/PXD072371; |
Keyword List
| submitter keyword: brain, AD, glycoproteomics, human,Cognition |
Contact List
| Yishai Levin |
|---|
| contact affiliation | Weizmann Institute of Science |
| contact email | yishai.levin@weizmann.ac.il |
| lab head | |
| Yishai Levin |
|---|
| contact affiliation | Weizmann Institute of Science, Israel |
| contact email | yishai.levin@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD072371 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD072371
- Label: PRIDE project
- Name: Glycoproteome-Wide Discovery of Cortical Glycoproteins That May Provide Cognitive Resilience in Older Adults
