⮝ Full datasets listing
PXD072349
PXD072349 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | MARCO promotes cholangiocarcinogenesis by inducing immunosuppression and its targeting reduces tumour growth |
| Description | Cholangiocarcinoma (CCA) comprises a heterogeneous group of biliary malignant tumours with poor prognosis. Recent studies highlight the immune systems role in the development and progression of intrahepatic CCA (iCCA). In this study, we investigated the role of the scavenger receptor MARCO in iCCA. MARCO was found on a specific subtype of tumour-associated macrophages and linked to immunosuppression and extracellular matrix remodelling in iCCA. High MARCO expression in human iCCA tumours correlated with worse overall survival, T cell dysfunction and increased collagen depositition. Marco-/- mice were protected against iCCA development, with fewer innate immune cells related to TH2 responses and less fibrosis. Moreover, Marco-/- mice exhibited lower levels of immunosuppressive markers on macrophages and cytotoxic T cells, resulting in better survival and fewer lung metastases. The use of an anti-MARCO antibody further reduced tumour volume in wild-type mice. This study identifies MARCO as a new therapeutic target in iCCA. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-02-11 |
| AnnouncementXML | Submission_2026-02-11_06:57:16.112.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | CIC Biogune |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-12-23 05:38:12 | ID requested | |
| ⏵ 1 | 2026-02-11 06:57:16 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: tumour immunology, oncology, biliary cancer, immunotherapy, macrophages, innate immunity, DatasetType:Proteomics |
Contact List
| Maria Jesis Perugorria | |
|---|---|
| contact affiliation | Facultad de Medicina y Enfermeria. UPV-EHU |
| contact email | mariajesus.perugorria@ehu.eus |
| lab head | |
| Jesus Maria Banales | |
| contact affiliation | Biogipuzkoa HRI |
| contact email | jesus.banalesasurmendi@bio-gipuzkoa.eus |
| lab head | |
| CIC Biogune | |
| contact affiliation | CIC Biogune |
| contact email | iiloro@yahoo.com |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v11/MSV000100316/ |
