⮝ Full datasets listing
PXD072325
PXD072325 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Cardiomyocyte-Derived HSPB1 Regulates TGF-β1 Maturation and Inhibits Endothelial-to-Mesenchymal Transition in Myocardial Fibrosis after Infarction |
| Description | Myocardial fibrosis is a major contributor to heart failure after myocardial infarction (MI), primarily driven by endothelial-to-mesenchymal transition (EndoMT). Heat shock protein B1 (HSPB1) has cardioprotective functions, but its role in MI-induced fibrosis remains unclear. Here, we show that cardiomyocyte-derived HSPB1 regulates the maturation and secretion of TGF-β1, thereby modulating endothelial phenotype and fibrotic remodeling. HSPB1 overexpression reduced fibrosis and preserved cardiac function, while its knockdown aggravated collagen deposition and EndoMT activation. Mechanistically, HSPB1 suppressed pro-TGF-β1 disulfide bond formation and secretion of mature TGF-β1, leading to decreased Smad2/3 phosphorylation and fibroblast activation. These findings identify HSPB1 as a redox-sensitive regulator that links cardiomyocyte homeostasis with endothelial transition, providing a potential therapeutic target for post-infarction myocardial fibrosis. |
| HostingRepository | iProX |
| AnnounceDate | 2025-12-22 |
| AnnouncementXML | Submission_2025-12-22_18:10:50.045.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jia Wang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-12-22 18:10:11 | ID requested | |
| ⏵ 1 | 2025-12-22 18:10:50 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: post-myocardial infarction fibrosis, Endothelial-to-mesenchymal transition (EndoMT), Small molecule heat shock protein B1 (HSPB1), TGF-β1, Disulfide bond |
Contact List
| Xiehong Liu | |
|---|---|
| contact affiliation | Hunan Provincial People’s Hospital (The First Afliated Hospital of Hunan Normal University) |
| contact email | dolly9918@hunnu.edu.cn |
| lab head | |
| Jia Wang | |
| contact affiliation | Hunan Provincial People’s Hospital (The First Afliated Hospital of Hunan Normal University) |
| contact email | 16673233295@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
