PXD072203

PXD072203 is an original dataset announced via ProteomeXchange.

Title	Higher concentration of extracellular vesicles in plasma from ME/CFS patients, with protein cargo alterations implicating complement and coagulation pathways
Description	Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic and debilitating disease characterized by post-exertional malaise, fatigue and pain. Yet, its underlying biological mechanisms remain poorly understood. Extracellular vesicles (EVs) are nanoparticles carrying biological cargo and are involved in cell-cell communication. Plasma EVs reflect several disease states and may serve as minimally invasive biomarkers. We characterized the plasma EV profiles of ME/CFS patients (N=49) and healthy controls (N=50), by enriching for EVs by size-exclusion chromatography coupled to high-resolution quantitative proteomics.
HostingRepository	PRIDE
AnnounceDate	2026-09-10
AnnouncementXML	Submission_2026-09-09_19:22:15.734.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ingrid Maria Erika Ekman Stensland
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF fleX

Revision	Datetime	Status	ChangeLog Entry
0	2025-12-19 05:23:31	ID requested
⏵ 1	2026-09-09 19:22:16	announced

10.1016/j.bbrep.2026.102679;

Rydland A, Yran ES, Nyman TA, Strand EB, Tr, ø, seid AS, Ø, vsteb, ø R, Heinicke F, Lie BA, Viken MK, Exploring differences in protein cargo of extracellular vesicles from ME/CFS patient plasma compared to healthy controls. Biochem Biophys Rep, 47():102679(2026) [pubmed]

submitter keyword: Myalgic encephalomyelitis/chronic fatigue syndrome, Extracellular vesicles, LC-MS/MS

Tuula Nyman
contact affiliation	Proteomics core facility, Oslo University Hospital
contact email	t.a.nyman@medisin.uio.no
lab head
Ingrid Maria Erika Ekman Stensland
contact affiliation	Oslo University hospital
contact email	maria.stensland@medisin.uio.no
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/08/PXD072203

PRIDE project URI

• PRIDE
  1. PXD072203
     1. Label: PRIDE project
     2. Name: Higher concentration of extracellular vesicles in plasma from ME/CFS patients, with protein cargo alterations implicating complement and coagulation pathways