PXD072199

PXD072199 is an original dataset announced via ProteomeXchange.

Title	HIV-1 Nef protein promotes the proliferation of lymphoma cells by activating the NF-κB pathway
Description	The prevalence of lymphoma in people living with HIV is remarkably higher compared to that of the general population, and the overall survival is markedly lower compared to that of lymphoma patients without HIV. In this study, we have demonstrated that the HIV-encoded negative regulatory factor (Nef) directly promotes lymphoma cell proliferation. We have also observed that Nef significantly upregulates key genes and proteins of the NF-κB signaling pathway, thereby promoting growth of lymphoma cells. These observations underscore the increasingly recognized role of HIV-encoded proteins as oncogenic drivers, providing fundamental mechanistic insights into the manner in which viral factors exploit host signaling networks to fuel lymphomagenesis.
HostingRepository	iProX
AnnounceDate	2025-12-19
AnnouncementXML	Submission_2025-12-22_00:51:35.127.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yuan Yang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro; DiART quantitation analysis

Revision	Datetime	Status	ChangeLog Entry
0	2025-12-19 01:46:18	ID requested
⏵ 1	2025-12-22 00:51:35	announced

Dataset with its publication pending

submitter keyword: Human Immunodeficiency Virus (HIV), HIV-1 Nef, Lymphoma, NF-κB pathway

Yemiao Chen
contact affiliation	Department of Infectious Diseases, Chongqing Public Health Medical Center
contact email	yemiaochen@126.com
lab head
Yuan Yang
contact affiliation	Southwest University
contact email	youngy2023@outlook.com
dataset submitter

iProX dataset URI