⮝ Full datasets listing
PXD071998
PXD071998 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | MARK2 serves as a key regulator of host antiviral immunity through GEF-H1 phosphorylation at Ser645 in a microtubule-dependent manner |
| Description | Wang et al. identify MARK2 as a key regulator of innate antiviral immunity. The phosphorylation of GEF-H1 at Ser645 by MARK2 enhances TBK1 activation and induces IFN-β and interferon-stimulated genes. This establishes the MARK2–GEF-H1–TBK1 axis as a fundamental component of host antiviral defense. |
| HostingRepository | iProX |
| AnnounceDate | 2025-12-15 |
| AnnouncementXML | Submission_2025-12-14_22:48:15.953.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Xingmei Qi |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-12-14 22:47:06 | ID requested | |
| ⏵ 1 | 2025-12-14 22:48:16 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: GEF-H1, MARK2,TBK1 |
Contact List
| Sidong Xiong | |
|---|---|
| contact affiliation | Institutes of Biology and Medical Sciences, Soochow University |
| contact email | sdxiongfd@126.com |
| lab head | |
| Xingmei Qi | |
| contact affiliation | Soochoow University |
| contact email | xmqi@suda.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
