PXD071939

PXD071939 is an original dataset announced via ProteomeXchange.

Title	S-Nitrosothiols modulate Porphyromonas gingivalis virulence
Description	Porphyromonas gingivalis is the key etiological pathogen of periodontal disease, a chronic oral inflammatory condition that affects over 14% of the global population. P. gingivalis possesses several potent virulence factors—including gingipains, hemagglutinins, and fimbriae—that drive microbial dysbiosis. To restore homeostasis, nitric oxide (NO) is endogenously produced by immune cells to eliminate the infection[HL1.1], but disease persistence necessitates the use of therapeutic agents. The multiple antibacterial mechanisms of NO minimize the potential for antimicrobial resistance compared to traditional antibiotics, making exogenous NO delivery a potential attractive strategy for combating P. gingivalis. The objective of this study was to evaluate the effect of exogenous NO on the virulence of P. gingivalis, including NO’s capacity to influence biofilm formation and dispersion, invasion of host cells, mitigation of immune response, and gingipain activity and production. Nitric oxide effectively modulated the virulent behavior of P. gingivalis by reducing the pathogen’s ability to form biofilms and invade host cells. Nitric oxide exposure also altered the pathogen’s ability to export gingipains, thereby significantly reducing its pathogenicity. This work highlights the therapeutic potential of exogenous NO to alter periodontal disease through its multimodal effects on the virulence of P. gingivalis.
HostingRepository	PRIDE
AnnounceDate	2026-08-20
AnnouncementXML	Submission_2026-08-19_22:38:26.747.xml
DigitalObjectIdentifier	https://doi.org/10.6019/PXD071939
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Leslie Hicks
SpeciesList	scientific name: Porphyromonas gingivalis ATCC 33277; NCBI TaxID: NEWT:431947;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2025-12-12 20:50:27	ID requested
⏵ 1	2026-08-19 22:38:27	announced

10.1016/J.REDOX.2026.104340;

10.6019/PXD071939;

submitter keyword: virulence, nitric oxide,periodontal disease, Porphyromonas gingivalis

Dr. Leslie Hicks
contact affiliation	Department of Chemistry, University of North Carolina at Chapel Hill
contact email	lmhicks@unc.edu
lab head
Leslie Hicks
contact affiliation	University of North Carolina at Chapel Hill
contact email	lmhicks@unc.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/08/PXD071939

PRIDE project URI

• PRIDE
  1. PXD071939
     1. Label: PRIDE project
     2. Name: S-Nitrosothiols modulate Porphyromonas gingivalis virulence