PXD071908 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Identification of Aryl Hydrocarbon Receptor (AhR) as a Functional Target that Enhances Astrocytic ApoE Secretion |
| Description | We discovered a chemical series that enhances ApoE secretion from human astrocytes through mechanisms independent of LXR agonism. Using chemoproteomics, photoaffinity probes, KINOMEscan analysis, and siRNA knockdowns, we identified the aryl hydrocarbon receptor (AhR), a transcription factor not previously linked to ApoE secretion, as the primary target. AhR antagonism was confirmed to increase ApoE secretion through a panel of agonists/antagonists and genetic knockdown. While chronic AhR inhibition is unsuitable for Alzheimer's treatment due to peripheral effects, these findings highlight AhR as a modulator of ApoE secretion and a pathway worth further exploration. There is two datasets deposited for this project. One dataset was generated through affinity chromatography enrichment, and the second dataset was generated through photo-affinity chromatography enrichment. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-01-12 |
| AnnouncementXML | Submission_2026-01-12_12:45:36.812.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD071908 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Bekim Bajrami |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-12-12 05:06:59 | ID requested | |
| ⏵ 1 | 2026-01-12 12:45:37 | announced | |
Publication List
Keyword List
| ProteomeXchange project tag: Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project |
| submitter keyword: Target ID, LC-MS/MS |
Contact List
| Kirk Donovan |
|---|
| contact affiliation | Chemical Biology and Proteomics group, Research department at Biogen |
| contact email | kirk.donovani@biogen.com |
| lab head | |
| Bekim Bajrami |
|---|
| contact affiliation | Biogen |
| contact email | bekim.bajrami@biogen.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD071908 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD071908
- Label: PRIDE project
- Name: Identification of Aryl Hydrocarbon Receptor (AhR) as a Functional Target that Enhances Astrocytic ApoE Secretion
