⮝ Full datasets listing
PXD071856
PXD071856 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomics data for: Pan-Apoptotic Protein Signature as a Novel Diagnostic and Prognostic Biomarker for Intracerebral Hemorrhage |
| Description | Intracerebral hemorrhage (ICH) remains a major cause of morbidity and mortality, with no rapid blood-based biomarkers available to assess secondary brain injury. This study aimed to identify a circulating pan-cell death protein signature for diagnosing and prognosing ICH. We prospectively enrolled 60 ICH patients and 60 age/sex-matched healthy controls, collecting plasma at defined time points after ICH onset. Using Olink® proteomics, we identified 13 apoptosis-related proteins with significant dysregulation. Four key proteins—TLR4, ALOX15, FTL, and BMF—were validated through ELISA and RT-qPCR, showing good diagnostic performance (AUCs 0.799–0.835). A multi-protein logistic model demonstrated excellent diagnostic accuracy (AUC = 0.955). These biomarkers correlated with clinical severity and prognosis, including hematoma volume and 90-day modified Rankin Scale (mRS). Additionally, animal models confirmed time-dependent upregulation of TLR4 in astrocytes. This pan-cell death protein signature provides valuable insights into ICH pathology and offers a promising tool for early diagnosis, risk stratification, and therapeutic targeting. |
| HostingRepository | iProX |
| AnnounceDate | 2025-12-11 |
| AnnouncementXML | Submission_2025-12-11_00:10:42.095.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Nan Zhao |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-12-11 00:09:15 | ID requested | |
| ⏵ 1 | 2025-12-11 00:10:42 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: intracerebral hemorrhage, pan-cell death, biomarkers |
Contact List
| Nan Zhao | |
|---|---|
| contact affiliation | The first Hospital of Kunming |
| contact email | zn15877991832@outlook.com |
| lab head | |
| Nan Zhao | |
| contact affiliation | The first Hospital of Kunming |
| contact email | zn15877991832@outlook.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
