PXD071853

PXD071853 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Ischemic cardiac organoid proteome map
Description	In this study, we demonstrate the use of human cardiac organoids (comprised of cardiomyocyte, fibroblast, and endothelial origin) to model IR injury through a model of hypoxia and reoxygenation and therapeutic nanovesicle remodelling. Engineered nanovesicles (NVs), generated directly from human stem cells (SC), have been shown to influence cardiac tissue repair, and provide a platform for the reproducible, rapid, and scalable cell free-mediated therapy. Functionally, we demonstrate that administration of NVs (from different human induced pluripotent stem cell (iPSC) origin) during reoxygenation significantly increase cardiomyocyte survival and preserve contractility function (contractile duration, relaxation time, relaxation:contraction velocity). A mass-spectrometry-based proteomics approach was applied to decipher protein dynamics and molecular mechanisms of IR injury in human cardiac organoids following NV treatments
HostingRepository	MassIVE
AnnounceDate	2025-12-10
AnnouncementXML	Submission_2025-12-10_21:00:22.429.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	David Greening
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	Acetyl
Instrument	Q Exactive HF-X

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-12-10 20:39:20	ID requested
⏵ 1	2025-12-10 21:00:22	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: cardiac, organoids, Ischemic, proteome remodelling, DatasetType:Proteomics

submitter keyword: cardiac, organoids, Ischemic, proteome remodelling, DatasetType:Proteomics

Contact List

David Greening
contact affiliation	Baker Heart & Diabetes Institute
contact email	david.greening@baker.edu.au
lab head
David Greening
contact affiliation	Baker Heart & Diabetes Institute
contact email	david.greening@baker.edu.au
dataset submitter

Full Dataset Link List

MassIVE dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v11/MSV000100182/

MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v11/MSV000100182/