PXD071844

PXD071844 is an original dataset announced via ProteomeXchange.

Title	The antioxidant network acts as a firewall in maintenance of genomic integrity
Description	we report a negative correlation between oxidative DNA damage and activity of the antioxidant enzymes. Multiple antioxidant networks formed by interactions between the antioxidant enzymes and the proteins essential for maintenance of genomic integrity are indentified in the nucleus by multi-proteomic assays. The protein-protein interactions in these networks are significantly up-regulated under oxidative stress, as evidenced by quantitative proximity ligation assays in situ within single cells. The antioxidant enzymes in the networks catalyze the ROS dismutation cascade before ROS attacks the Fe-S cluster, thereby preventing DNA and the enzymes from oxidative damage and dysfunction. Our findings implicate that the antioxidant networks serve as a firewall role in maintenance of genomic integrity.
HostingRepository	iProX
AnnounceDate	2025-12-10
AnnouncementXML	Submission_2025-12-10_18:17:20.742.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Geng He
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive; Orbitrap Fusion Lumos; Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2025-12-10 18:16:48	ID requested
⏵ 1	2025-12-10 18:17:21	announced

Dataset with its publication pending

submitter keyword: DIA, genomic integrity, antioxidant networks, SOD1

Xiang Li
contact affiliation	Hubei University
contact email	lixiang199284@hubu.edu.cn
lab head
Geng He
contact affiliation	Central China Normal University
contact email	genghe@mails.ccnu.edu.cn
dataset submitter

iProX dataset URI