PXD071776

PXD071776 is an original dataset announced via ProteomeXchange.

Title	Repurposing Trazodone for Alzheimer's Disease to Modulate Soluble ST2 Levels and Alleviate Alzheimer's Pathology
Description	Drug repurposing offers a cost-effective strategy for accelerating therapeutic development. This study identifies trazodone, an FDA-approved anti-depressant, as a promising therapeutic candidate for Alzheimer’s disease (AD). We show that trazodone use in patients with AD is associated with decreased levels of soluble ST2 (sST2), a known disease-modifying factor in AD. In the APP/PS1 transgenic mouse model of AD, trazodone treatment enhances microglial interactions with amyloid-beta (Aβ) and alleviates Aβ pathology. Additionally, trazodone rescues synaptic deficits and restores the expression of synaptic proteins in APP/PS1 mice. These findings demonstrate the therapeutic potential of repurposing trazodone to target immune and synaptic dysfunctions in AD, providing a novel therapeutic avenue for this debilitating condition.
HostingRepository	PRIDE
AnnounceDate	2026-07-02
AnnouncementXML	Submission_2026-07-01_18:50:32.170.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Daniel Yew Kit Wong
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-12-09 12:25:55	ID requested
⏵ 1	2026-07-01 18:50:32	announced

Dataset with its publication pending

submitter keyword: None

Nancy Yuk-Yu
contact affiliation	Room 6313, Academic building, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon
contact email	iplabgenetics@gmail.com
lab head
Daniel Yew Kit Wong
contact affiliation	Hong Kong University of Science and Technology
contact email	ykdwong@connect.ust.hk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD071776

PRIDE project URI

• PRIDE
  1. PXD071776
     1. Label: PRIDE project
     2. Name: Repurposing Trazodone for Alzheimer's Disease to Modulate Soluble ST2 Levels and Alleviate Alzheimer's Pathology