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PXD071621
PXD071621 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Rational Design of AI-Driven Self-Assembling Antimicrobial Peptides and Investigation of Their Mechanism Against Multidrug-Resistant Bacterial Infections |
| Description | With the growing severity of antibiotic resistance, the development of novel antimicrobial agents is urgently needed. Antimicrobial peptides (AMPs) have emerged as a research hotspot due to their broad-spectrum activity and low resistance potential, yet traditional development methods remain inefficient. This study integrates artificial intelligence (AI) with self-assembly engineering strategies, utilizing the lead peptide SMAP-29 as a template for optimization. Through a multi-step AI framework (combining generative and discriminative models), the more potent and safer derivative peptide SMAP10A was efficiently designed. SMAP10A demonstrated outstanding efficacy against multidrug-resistant bacteria both in vitro and in vivo, with a potential mechanism involving targeting membrane phospholipids and inducing reactive oxygen species accumulation. This project aims to further introduce hydrophobic modifications to the peptide chain, inducing its self-assembly into nanostructures to enhance membrane interaction, stability, and in vivo efficacy. This work not only provides a potent candidate molecule against resistant bacteria but also establishes a scalable AI-driven AMP development paradigm, significantly accelerating the discovery of novel antimicrobial agents. |
| HostingRepository | iProX |
| AnnounceDate | 2025-12-04 |
| AnnouncementXML | Submission_2025-12-04_22:51:46.471.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Zhenfeng Wang |
| SpeciesList | scientific name: Staphylococcus aureus; NCBI TaxID: 1280; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive Plus |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-12-04 22:51:32 | ID requested | |
| ⏵ 1 | 2025-12-04 22:51:46 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Self-assembling nanopeptides, multidrug-resistant bacteria |
Contact List
| Wenze Wen | |
|---|---|
| contact affiliation | Department of Infectious Diseases and Shenzhen Key Laboratory for Endogenous Infections, Shenzhen Nanshan People’s Hospital, Shenzhen, China |
| contact email | wenzw05@163.com |
| lab head | |
| Zhenfeng Wang | |
| contact affiliation | Clinical Medical College, Jiamusi University, Jiamusi, Heilongjiang, China |
| contact email | wzf120317@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
