PXD071497

PXD071497 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	BAP1 dysregulation impairs trophoblast differentiation and contributes to placental dysfunction in preeclampsia
Description	This dataset profiles the proteomic effects of altering BAP1 expression in human trophoblast stem cells and trophoblast organoids. Samples from control, BAP1-overexpressing, and BAP1-knockdown conditions were analyzed by LC–MS/MS. DIA-NN–based quantification and differential analysis revealed BAP1-dependent changes affecting trophoblast differentiation, inflammatory signaling, and pathways linked to early-onset preeclampsia.
HostingRepository	PRIDE
AnnounceDate	2026-03-24
AnnouncementXML	Submission_2026-03-24_06:52:22.225.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sergio Navarro
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF fleX

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-12-02 18:11:40	ID requested
⏵ 1	2026-03-24 06:52:22	announced

Publication List

10.1038/S41419-026-08650-Z;

10.1038/S41419-026-08650-Z;

Keyword List

submitter keyword: organoids, trophoblast,BAP1, early-onset preeclampsia, placenta

submitter keyword: organoids, trophoblast,BAP1, early-onset preeclampsia, placenta

Contact List

Vicente Perez-Garcia
contact affiliation	Centro de Biología Molecular (CBM)
contact email	vperez@cbm.csic.es
lab head
Sergio Navarro
contact affiliation	Centro de Biología Molecular (CBM)
contact email	sergio.navarro@cbm.csic.es
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD071497
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD071497

PRIDE project URI

Repository Record List

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