PXD071328

PXD071328 is an original dataset announced via ProteomeXchange.

Title	Adherens junction protein expression is associated with poor response to neoadjuvant FLOT chemotherapy and pro-inflammatory tumor microenvironment in esophageal adenocarcinoma
Description	Esophageal adenocarcinomas represent aggressive gastrointestinal malignancies, characterized by poor survival and variable responses to perioperative therapies. Our study identified a significant association between adherens junction (AJ) protein expression and treatment response to FLOT chemotherapy. We demonstrate that AJ dysregulation occurs across histological subtypes and correlates with pro-inflammatory tumor microenvironment and extracellular matrix remodeling. These findings provide a foundation which could guide treatment selection, potentially avoiding ineffective therapies while identifying patients for alternative approaches. The adenocarcinoma samples analyzed in this study were part of a larger cohort for mass spectrometry proteomic analysis that also included esophageal squamous cell carcinomas (PEC) and normal esophageal tissue. All samples from this comprehensive cohort were preprocessed together up to and including the analysis of protein expression quantification, and the complete dataset is deposited in this upload.
HostingRepository	PRIDE
AnnounceDate	2026-01-07
AnnouncementXML	Submission_2026-01-06_16:29:52.648.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Proteomics Facility
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2025-11-27 08:58:31	ID requested
⏵ 1	2026-01-06 16:29:53	announced

Dataset with its publication pending

submitter keyword: esophageal adenocarcinoma, FLOT perioperative treatment, cell adhesion, tumor microenvironment

Alexander Quaas
contact affiliation	Institute of Pathology University Hospital Cologne Kerpener Straße 62, Cologne, Germany
contact email	alexander.quaas@uk-koeln.de
lab head
Proteomics Facility
contact affiliation	CECAD Research Center
contact email	proteomics-facility@uni-koeln.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD071328

PRIDE project URI

• PRIDE
  1. PXD071328
     1. Label: PRIDE project
     2. Name: Adherens junction protein expression is associated with poor response to neoadjuvant FLOT chemotherapy and pro-inflammatory tumor microenvironment in esophageal adenocarcinoma