PXD071237

PXD071237 is an original dataset announced via ProteomeXchange.

Title	Multi-phase hybrid metabolomics framework identifies clinically applicable plasma signatures for early detection of gastric cancer
Description	Plasma metabolomics offers significant potential for non-invasive biomarker discovery in gastric cancer (GC), yet conventional analytical workflows face challenges in absolute quantification and biological interpretability, hindering clinical translation. We present an innovative multi-phase hybrid framework integrating untargeted metabolomics with relative- and absolute-quantitative targeted metabolomics, coupled with a custom interpretability-driven algorithm for de novo biomarker identification. Metabolic profiling was performed using 1,706 plasma samples from multicenter cohorts. The relative-quantitation phase identified 84 key metabolites significantly enriched in caffeine metabolism and primary bile acid biosynthesis pathways. By applying the custom algorithm to absolute quantitation data, we established a 12-metabolite panel covering multiple functional metabolic modules. Machine learning-based diagnostic models using this signature achieved an area under the curve of 0.951 in validation cohort. Together, our study provides a robust and interpretable framework for translational metabolomics and establishes a GC detection biomarker panel, laying the foundation for future mechanistic research and clinical application.
HostingRepository	iProX
AnnounceDate	2025-11-24
AnnouncementXML	Submission_2026-06-03_01:56:41.749.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Liyi Bai
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	QTRAP 6500+

Revision	Datetime	Status	ChangeLog Entry
0	2025-11-25 18:09:09	ID requested
1	2026-04-19 17:09:24	announced
⏵ 2	2026-06-03 01:56:42	announced	2026-06-03: Add info

Bai L, Hu F, Zhang W, Peng H, Peng H, Li H, Zhu X, Xie Y, Zhang S, Min L, Multi-phase hybrid metabolomics framework identifies clinically applicable plasma signatures for early detection of gastric cancer. Nat Commun, ():(2026) [pubmed]

submitter keyword: plasma, metabolomic, noninvasive, biomarker, gastric cancer

Min Li
contact affiliation	Beijing Friendship Hospital, Capital Medical University
contact email	minli@ccmu.edu.cn
lab head
Liyi Bai
contact affiliation	Beijing Friendship Hospital, Capital Medical University
contact email	baily@ccmu.edu.cn
dataset submitter

iProX dataset URI