PXD071231 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Quantitative proteomics of the lung in a Thbs1 cell specific knockout model after pseudomonal injury in mice |
| Description | An early event after lung injury is extracellular matrix (ECM) remodeling and the formation of a provisional matrix. While megakaryocytes (Mgks) and platelets play important roles in hemostasis, their impact on the matrix in lung injury is not fully understood. We utilized quantitative proteomics to demonstrate that matricellular protein thrombospondin-1 (TSP1) arising from Mgk/plts protects the lung from acute alveolar injury. Given the essential role of Mgk/plts in forming the provisional matrix. We explored matrix-related proteins within the airspace compartment and alveolar tissue compartment after injury following pseudomonal lung infection in wildtype and cell specific Thbs1 knockout mouse model systems. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-02-20 |
| AnnouncementXML | Submission_2026-02-20_05:14:51.100.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Donovan Watza |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro; LTQ Orbitrap Elite |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-11-25 17:52:26 | ID requested | |
| ⏵ 1 | 2026-02-20 05:14:51 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
Contact List
| Janet Lee |
|---|
| contact affiliation | Washington University, Department of Medicine, Division of Pulmonary and Critical Care |
| contact email | ljanet@wustl.edu |
| lab head | |
| Donovan Watza |
|---|
| contact affiliation | Washington University |
| contact email | d.g.watza@wustl.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD071231 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD071231
- Label: PRIDE project
- Name: Quantitative proteomics of the lung in a Thbs1 cell specific knockout model after pseudomonal injury in mice
