PXD071139

PXD071139 is an original dataset announced via ProteomeXchange.

Title	The TLR10–Vitamin D Axis Facilitates Osteogenic DifferThe TLR10–Vitamin D Axis Facilitates Osteogenic Differentiation of Mesenchymal Stem Cells in vitroentiation of Mesenchymal Stem Cells in vitro
Description	Bone regeneration depends on the coordinated interplay between mesenchymal stem cells (MSCs), immune-derived signals, and processes of extracellular matrix (ECM) remodeling. While most Toll-like receptors (TLRs) evoke pro-inflammatory responses that impair osteogenesis, the role of the atypical, immunomodulatory receptor TLR10 in MSC biology remains largely unexplored. Here, we investigated whether TLR10 serves as a regulatory node integrating innate immune signaling with vitamin D–driven osteogenic differentiation in human adipose-derived MSCs. ASC/TERT1 MSCs were engineered to overexpress or silence TLR10 using lentiviral vectors.
HostingRepository	PRIDE
AnnounceDate	2026-05-22
AnnouncementXML	Submission_2026-05-22_08:02:09.211.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Benjamin Neuditschko
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Eclipse

Revision	Datetime	Status	ChangeLog Entry
0	2025-11-24 11:37:15	ID requested
⏵ 1	2026-05-22 08:02:09	announced

10.3390/CELLS15080697;

submitter keyword: osteogenic differentiation, vitamin D signaling, mesenchymal stem cells,Toll-like receptor 10

Franz Herzog
contact affiliation	Institute Krems Bioanalytics, IMC University of Applied Sciences, 3500, Krems, Austria
contact email	franz.herzog@imc.ac.at
lab head
Benjamin Neuditschko
contact affiliation	Institute Krems Bioanalytics, IMC University of Applied Sciences Krems, 3500 Krems, Austria
contact email	benjamin.neuditschko@fh-krems.ac.at
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD071139

PRIDE project URI

• PRIDE
  1. PXD071139
     1. Label: PRIDE project
     2. Name: The TLR10–Vitamin D Axis Facilitates Osteogenic DifferThe TLR10–Vitamin D Axis Facilitates Osteogenic Differentiation of Mesenchymal Stem Cells in vitroentiation of Mesenchymal Stem Cells in vitro