PXD071137 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Chaperone-mediated autophagy regulates macrophage clearance of senescent cells |
| Description | Autophagy dysfunction and senescence are established drivers of aging, but their interplay remains poorly understood. Here, we identify how the age-related decline in chaperone-mediated autophagy (CMA) affects properties and fate of senescent cells in old organisms. Cells with genetically downregulated CMA, mimicking its aging decline, still undergo senescence but display a distinct senescence-associated secretory phenotype, and proteomic and metabolic profiles phenocopying those in old senescent cells. Combined CMA decline in senescent cells and macrophages impair senescent cell clearance. In fact, macrophage-specific CMA blockage in mice is sufficient for senescent cell accumulation, highlighting a key role for macrophage CMA in their recognition and removal. Conversely, pharmacological CMA activation reduces senescent cell burden in old mice and disease severity in a pulmonary fibrosis mouse model. Our findings reveal a functional interplay between CMA decline and senescence cell persistence, highlighting CMA upregulation as a promising strategy to promote senescence resolution in old organisms. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-08-21 |
| AnnouncementXML | Submission_2026-08-21_10:25:52.408.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Simone Sidoli |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion Lumos; timsTOF HT |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-11-24 10:47:19 | ID requested | |
| ⏵ 1 | 2026-08-21 10:25:52 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Aging |
| Immune Clearance |
| Lysosomes |
| Proteostasis |
| Senescence |
Contact List
| Simone Sidoli |
|---|
| contact affiliation | Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, United States |
| contact email | simone.sidoli@einsteinmed.edu |
| lab head | |
| Simone Sidoli |
|---|
| contact affiliation | Albert Einstein College of Medicine |
| contact email | simone.sidoli@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/08/PXD071137 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD071137
- Label: PRIDE project
- Name: Chaperone-mediated autophagy regulates macrophage clearance of senescent cells
