⮝ Full datasets listing
PXD071044
PXD071044 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomics Analysis of Cerebrospinal Fluid in Survivors of Childhood Acute Lymphoblastic Leukemia |
| Description | Mass spectrometry-based proteomic profiling of cerebrospinal fluid (CSF) in large patient cohorts, particularly among childhood cancer survivors, remains scarce, limiting opportunities for benchmarking, method development, and validation. Here, we present a longitudinal CSF proteomics dataset from survivors of childhood acute lymphoblastic leukemia (ALL). Samples were collected from 178 patients enrolled in the TOTXVI therapeutic protocol at two timepoints: diagnosis (pre-treatment) and during the consolidation phase of chemotherapy (totaling 356 samples). CSF proteomes were profiled using tandem-mass-tag (TMT) labeling coupled with extensive fractionation and high-resolution liquid chromatography-tandem mass spectrometry (LC/LC-MS/MS). The dataset includes quantitative profiles for more than 3,000 confidently identified proteins. This resource enables the investigation of chemotherapy-induced alterations in the CSF proteome and provides a valuable resource for studying the molecular mechanisms of neurotoxicity, identifying biomarkers of adverse late effects, and guiding the development of neuroprotective strategies in childhood cancer survivors. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-01-05 |
| AnnouncementXML | Submission_2026-01-05_10:18:21.920.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Him Shrestha |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | Carbamidomethyl; Oxidation |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-11-21 08:23:01 | ID requested | |
| ⏵ 1 | 2026-01-05 10:18:22 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Cerebrospinal Fluid, Childhood Acute Lymphoblastic Leukemia, Chemotherapy, childhood cancer survivors, LC/LC-MS/MS, DatasetType:Proteomics |
Contact List
| Junmin Peng | |
|---|---|
| contact affiliation | St. Jude Children's Research Hospital |
| contact email | junmin.peng@stjude.org |
| lab head | |
| Him Shrestha | |
| contact affiliation | St. Jude Children's Research Hospital |
| contact email | hshresth@stjude.org |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v11/MSV000099982/ |
