PXD070953 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | A lipoprotein partner for the Escherichia coli outer membrane protein TolC |
| Description | TolC is an outer-membrane protein that serves as an activated exit duct in multi-drug efflux pumps and protein secretion machinery. We have discovered that the E. coli lipoprotein YbjP interacts extensively with the periplasmic surface of TolC and its N-terminal lipid moiety is embedded in the membrane, mimicking the intramolecular and modification-membrane interactions seen in TolC homologs. Our results suggest that YbjP may contribute to stabilising the orientation and distribution of TolC in the outer membrane as well as the expression of transporters. The accompanying data corresponds to DIA mass spectra from tolC, ybjP, tolC-ybjP mutants, as well as WT E. coli as a reference. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-03-27 |
| AnnouncementXML | Submission_2026-03-27_14:11:42.464.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Ben Luisi |
| SpeciesList | scientific name: Escherichia coli BW25113; NCBI TaxID: NEWT:679895; |
| ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Bruker Daltonics timsTOF series |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-11-19 12:22:26 | ID requested | |
| ⏵ 1 | 2026-03-27 14:11:42 | announced | |
Publication List
Keyword List
| submitter keyword: DIA,tolC, ybjP |
Contact List
| Ben Luisi |
|---|
| contact affiliation | Department of Biochemistry, University of Cambridge |
| contact email | bfl20@cam.ac.uk |
| lab head | |
| Ben Luisi |
|---|
| contact affiliation | Department of Biochemistry
Cambridge |
| contact email | bfl20@cam.ac.uk |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD070953 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD070953
- Label: PRIDE project
- Name: A lipoprotein partner for the Escherichia coli outer membrane protein TolC
