⮝ Full datasets listing
PXD070905
PXD070905 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | The transmembrane protein disulfide isomerase TMX3 potentiates platelet aggregation and arterial thrombosis in mice |
| Description | To identify the specific disulfide bonds in alphaIIbbeta3 catalyzed by TMX3, alphaIIbbeta3 protein was incubated with GSH (group 1), GSH plus TMX3 (group 2), or DTT (group 3). After incubation, free thiols were labeled with IAM, excess IAM was removed by Zeba column, and the remaining disulfide bonds were subsequently reduced by DTT and labeled with NEM, excess NEM was removed by Zeba column. The abundance of Cys-IAM was then quantified by mass spectrometry. |
| HostingRepository | MassIVE |
| AnnounceDate | 2025-12-11 |
| AnnouncementXML | Submission_2025-12-11_09:30:40.974.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Fengwu Chen |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | N-ethylmaleimide derivatized cysteine; CarbamidomethylDTT |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-11-18 13:20:23 | ID requested | |
| ⏵ 1 | 2025-12-11 09:30:41 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: TMX3, alphaIIbbeta3, disulfide bond, DatasetType:Proteomics |
Contact List
| Fengwu Chen | |
|---|---|
| contact affiliation | Tsinghua University |
| contact email | fengwu_chen@126.com |
| lab head | |
| Fengwu Chen | |
| contact affiliation | Tsinghua University |
| contact email | fengwu_chen@126.com |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v11/MSV000099946/ |
