PXD070815

PXD070815 is an original dataset announced via ProteomeXchange.

Title	Dynamic Proteomics Identifies Biomarkers for Breast Cancer Subtyping and Early Lymphatic Metastasis Grading
Description	Herein, we proposed an integrated platform combining organoid modeling with longitudinal EV proteomics to accelerate dynamic biomarker discovery, addressing the problem of costly and time-consuming detection of lymphatic metastasis in heterogeneous BC progression. And for precise EV proteomic analysis of individual organoids, all organoids were cultured separately and analyzed. By using ultra-sensitive mass spectrometry method for their EV proteomics, we obtained time-resolved, in-depth EV proteomic profiling that captures evolving molecular signatures during organoid progression, and multi-level clinical validation emphasizes the diagnostic potential of screened markers by using matched tissue and plasma.
HostingRepository	iProX
AnnounceDate	2025-11-17
AnnouncementXML	Submission_2025-11-17_00:52:21.004.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jie Sun
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-11-17 00:51:54	ID requested
⏵ 1	2025-11-17 00:52:21	announced

Dataset with its publication pending

submitter keyword: Breast Cancer, Organoid, Extracellular Vesicles, Proteomics, Early Lymph Node Metastasis

Zhuoying Xie
contact affiliation	State Key Laboratory of Digital Medicine Engineering
contact email	zyxie@seu.edu.cn
lab head
Jie Sun
contact affiliation	State Key Laboratory of Digital Medicine Engineering
contact email	15850668861@163.com
dataset submitter

iProX dataset URI