⮝ Full datasets listing
PXD070791
PXD070791 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Investigating the Pathogenic Mechanism of a C-Terminal Desmoplakin (DSP) Mutation in Palmoplantar Keratoderma through Gene Knockdown in HaCaT Keratinocytes and Comparative Quantitative Proteomic Analysis to Identify Dysregulated Signaling Pathways |
| Description | We identified a C-terminal mutation in the Desmoplakin (DSP) gene in a patient with palmoplantar keratoderma (PPK). To explore the pathogenic mechanism, we knocked down DSP expression in human HaCaT keratinocytes and performed a comparative proteomic analysis with normal cells. This study aims to elucidate the role of DSP mutations in PPK pathogenesis. |
| HostingRepository | iProX |
| AnnounceDate | 2025-11-14 |
| AnnouncementXML | Submission_2025-11-16_16:31:22.093.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Chunli Lin |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-11-16 16:31:03 | ID requested | |
| ⏵ 1 | 2025-11-16 16:31:22 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Palmoplantar Keratoderma ,DSP |
Contact List
| Longnian Li | |
|---|---|
| contact affiliation | First Affiliated Hospital of Gannan Medical University |
| contact email | li_longnian@foxmail.com |
| lab head | |
| Chunli Lin | |
| contact affiliation | First Affiliated Hospital of Gannan Medical University |
| contact email | 15260012771@139.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
