PXD070640

PXD070640 is an original dataset announced via ProteomeXchange.

Title	Proteomic profiling of in vitro knockdown of SMARCA4 in Medulloblastoma
Description	SMARCA4 mutations are common in Medulloblastoma but not much is understood about its pathobiology. In this study we prepared SMARCA4 knockdown models using a Group 3 medulloblastoma cell line called HDMB03 and investigated the proteomic changes. We performed both DDA and DIA analyses and found that DIA performed better for our study. Our findings highlight that SMARCA4 loss disrupts proliferative and chromatin-regulatory networks while inducing metabolic reprogramming in vitro Group 3 MB.
HostingRepository	jPOST
AnnounceDate	2026-03-25
AnnouncementXML	Submission_2026-03-24_08:00:36.629.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Medha Gayathri Pai
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2025-11-12 10:16:58	ID requested
⏵ 1	2026-03-24 08:00:37	announced

Dataset with its publication pending

submitter keyword: SMARCA4, Group 3 medulloblastoma, chromatin remodeling, proteomics, data-independent acquisition, lipid metabolism

Prof. Sanjeeva Srivastava
lab head
Medha Gayathri Pai
contact affiliation	Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra 400076, India.
dataset submitter

jPOST dataset URI

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