PXD070576

PXD070576 is an original dataset announced via ProteomeXchange.

Title	COL1A2 loss in placental fibroblasts drives an activated and fibrosis-like phenotype
Description	Preeclampsia is a serious pregnancy-induced disorder unique to humans affecting 4.6% of pregnancies worldwide. Advances in the detection, prevention and treatment of preeclampsia have been poor due to our inadequate understanding of its pathogenesis. Here, we performed a proteomics study on isolated primary pregnancy placental fibroblasts treated with siRNA against COL1A2. Loss of COL1A2 in placental fibroblasts significantly dysregulated 74 proteins (39 upregulated, 35 downregulated), which were enriched for pathways including ECM remodeling/wound healing, coagulation and fibrinolysis. Our study provides critical insight into the early pregnancy dysfunction underlying preeclampsia, opening up new avenues for predictive biomarker and preventative treatment discovery.
HostingRepository	PRIDE
AnnounceDate	2026-06-09
AnnouncementXML	Submission_2026-06-08_22:33:50.958.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ellen Menkhorst
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Ascend

Revision	Datetime	Status	ChangeLog Entry
0	2025-11-10 23:50:27	ID requested
⏵ 1	2026-06-08 22:33:51	announced

Menkhorst E, Yang G, Yu Y, Santos LL, Zhou W, Syngelaki A, Varshney S, Williamson NA, Koga K, Rolnik DL, da Silva Costa F, Nicolaides K, L, ê, Cao KA, Dimitriadis E, Multi-Omics Reveals Early Pregnancy Placental Dysfunction Associated With Preterm and Term Preeclampsia. MedComm (2020), 7(6):e70784(2026) [pubmed]

10.1002/mco2.70784;

submitter keyword: Placenta, COL1A2, fibroblast

Ellen Menkhorst
contact affiliation	Department of Obstetrics, Gynecology and Newborn Health; The University of Melbourne
contact email	ellen.menkhorst@unimelb.edu.au
lab head
Ellen Menkhorst
contact affiliation	University of Melbourne
contact email	ellen.menkhorst@unimelb.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD070576

PRIDE project URI

• PRIDE
  1. PXD070576
     1. Label: PRIDE project
     2. Name: COL1A2 loss in placental fibroblasts drives an activated and fibrosis-like phenotype